New chiral agents for resolution of racemic cis-permethric and cis-Z-cyhalothric acids

✍ Scribed by Sergey A. Popov; Alexey V. Tkachev

• Publisher: Elsevier Science
• Year: 1995
• Tongue: English
• Weight: 339 KB
• Volume: 6
• Category: Article
• ISSN: 0957-4166
• DOI: 10.1016/0957-4166(95)00112-3

✦ Synopsis

Resolution of racemic pyrethroid acids (cis-permethric and cis-Z-cyhalothric)

using stable optically active amines derived from natural monoterpene (+)-3-carene and prepartion of optically active esters of the pyrethroid acids are described Optically active amines are known to be the most common used agents for resolution of racemic cyclopropanecarboxylic acids m ,2,3 In most cases these amines have poor stability on the open air and, besides, are readily soluble in water, so recycling of the optically active reagent is highly conjectural Now we report the use of stable 4 optically active amines 1 and 2 derived from natural monoterpene (+)-3-carene for the resolution of certain pyrethroid acids -(_+)-cis-permethric (3) and (±)-cis-Z-cyhalothric (4) acids.