New C-nucleoside analogs by dehydration of 1-benzyl-4,5,6,7-tetrahydro-6,6-dimethyl-2-(d-galacto-pentitol-1-yl)-indol-4-one
✍ Scribed by Emilio Román Galán; Jaun A. Galbis Pérez; Mariá A. Arévalo Arévalo
- Publisher
- Elsevier Science
- Year
- 1983
- Tongue
- English
- Weight
- 521 KB
- Volume
- 116
- Category
- Article
- ISSN
- 0008-6215
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📜 SIMILAR VOLUMES
The title hept-I -enitol( 2) reacted with aldehyde methyl(or phenyl)hydrazones in refluxing methanol or butyl acetate to give I-methyl(or phenyl)-5-(penta-O-acetyl-~-~~u~u~f~~-pentitol-l-yl)pyrazoles in good (for I-methylpyrazoles) or moderate yields (for I-phenylpyrazolcs). The 0-deacetylated produ
The structures of the title compounds (2b and 3) have been investigated in the solid state by X-ray methods. The crystals of 2b are monoclinic, space group P2,, and of 3 orthorhombit, space grtup P2,2,2,. The cell dimensions are: for 2b, a = 9.910(2), b = 11;745W, c = 11.810(3) A, /3 = 97.32(l)"; a
We have synthesized 14C-and 2H-labeled 1,3-dihydro-3,3dimethyl-5-(1,4,5,6-tetrahydro-6-oxo-3-pyridazinyl)-2H\_-indol-2one (LY195115), an extremely potent, orally-effective cardiotonic with inotropic and vasodilator activities. '\*C-label was introduced in the antepenultimate step by reaction of a B-