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New Bradykinin Analogues Modified in the C-Terminal Part with Sterically Restricted 1-Aminocyclohexane-1-carboxylic Acid

✍ Scribed by Labudda-Dawidowska, Olga; Wierzba, Tomasz H.; Prahl, Adam; Kowalczyk, Wioleta; Gawiński, Łukasz; Plackova, Marketa; Slaninová, Jiřina; Lammek, Bernard

Book ID: 121206007
Publisher: American Chemical Society
Year: 2005
Tongue: English
Weight: 69 KB
Volume: 48
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm0580353

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New bradykinin analogues substituted in

New bradykinin analogues substituted in positions 7 and 8 with sterically restricted 1-aminocyclopentane-1-carboxylic acid

✍ Olga Labudda; Tomasz Wierzba; Dariusz Sobolewski; Wioleta Kowalczyk; MAłgorzata 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 102 KB

## Abstract A sterically constrained non‐coded amino acid, 1‐aminocyclopentane‐1‐carboxylic acid (Apc), was introduced in position 7 or 8 of the bradykinin (BK) B~2~ receptor antagonist, [D‐Arg^0^, Hyp^3^, Thi^5, 8^, D‐Phe^7^]BK, previously synthesized by Stewart's group. This modification is belie