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New biology of aldosterone, and experimental studies on the selective aldosterone blocker eplerenone

โœ Scribed by John W. Funder


Book ID
117842968
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
88 KB
Volume
144
Category
Article
ISSN
1097-6744

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Interconversion pharmacokinetics of eple
โœ Chyung S. Cook; Liming Zhang ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 118 KB

The interconversion pharmacokinetics of eplerenone and its lactone-ring open form, SC-70303, were examined in dogs using a stable isotope method. [13CD3]EP and SC-70303 were coadministered orally (10 mg/kg) and intravenously (5 mg/kg) as aqueous solutions under fasted conditions. After I.V. administ