New biodegradable polymers of L-lactic acid and aromatic hydroxy acids and their applications in drug delivery systems
β Scribed by Kazumichi Imasaka; Masaru Yoshida; Hironobu Fukuzaki; Masaharu Asano; Minoru Kumakura; Tohru Mashimo; Hidetoshi Yamanaka; Tsuneji Nagai
- Book ID
- 113365661
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- English
- Weight
- 697 KB
- Volume
- 81
- Category
- Article
- ISSN
- 0378-5173
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## Abstract Starting from D,Lβacid and SnCl~2~ as catalyst, poly(D,Lβlactic acid) (PDLLA) was directly synthesized by melt polycondensation. Under the appropriate conditions such as 0.5 wt % SnCl~2~, 170β180Β°C, 70 Pa, and 10 h, the viscosityβaverage molecular weight (__M__~Ξ·~) of PDLLA was 4100 Da.
## Abstract The maximum steady state flux, diffusion coefficients, and solubilities of five contraceptive steroids in homopolymers and copolymers of Ο΅βcaprolactone and DLβlactic acid were determined. The permeabilities of polymers of Ο΅βcaprolactone were comparable to silicone rubber and, by inferen