✍ Scribed by Bilge ŞLener; Atta-Ur-Rahman Atta-Ur-Rahman
No coin nor oath required. For personal study only.
Turkey has a very rich flora and a long history of herbal medicine practices. The biological evaluation of substances from plant sources is highly relevant for the identification of lead compounds which can result in the development of novel and safe medicinal agents. During our extensive studies with Turkish medicinal plants, we have isolated and characterized a large number of natural products. Although Turkey is endowed with a wide variety of medicinal plants, very little effort has been made so far towards bioassay‐directed isolation of biologically active compounds from indigenous plants. During the past few years, we have also been engaged in the isolation and structure elucidation of compounds through a bioassay‐directed fractionation procedure.
In this manuscript, new bioactive steroidal alkaloids isolated from Buxus, Veratrum and Fritillaria species are presented. Among these, four steroidal alkaloids isolated from the leaves of Buxus longifolia have shown significant antibacterial activity against Salmonella typhi, Shigella flexneri, Escherichia coli and Pseudomonas aeruginosa. Three steroidal alkaloids from Veratrum album have been shown to have antihypertensive actions. In addition, a new steroidal base obtained from the bulbs of Fritillaria imperialis exhibited anticholinergic activity as manifested by the blockade of acetylcholine responses on isolated guinea‐pig ileum and atria.
📜 SIMILAR VOLUMES
China has accumulated a rich body of empirical knowledge of the use of medicinal plants for the treatment of various diseases throughout its long history. Chemical studies on Chinese medicinal plants provide a valuable material base for the discovery and development of new drugs of natural origin. I