New approaches to synthetic receptors. Synthesis and host properties of a water soluble macrocyclic analog of Tröger's base
✍ Scribed by Craig S. Wilcox; Marlon D. Cowart
- Publisher
- Elsevier Science
- Year
- 1986
- Tongue
- French
- Weight
- 178 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
✦ Synopsis
A water soluble, macrocyclic TrSger's base analog has been prepared and found to form association complexes with benzenoid substrates.
• In the last decade, pioneering work by Koga, Murakami, Tabushi and Whitlock demonstrated that simple water soluble cyclophanes were capable of forming inclusion complexes with benzenoid and naphthalenoid substrates. 1 More recently, Diederich has refined this approach to synthetic receptors and has prepared a water soluble cyclophane which has a high affinity (K d = 10 -4 to 10 -5 ) for naphthalenoid substrates. 2 The known water soluble cyclophanes are flexible molecules