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New approaches for the synthesis of isotopically labelled guanidine-derived amino acids and noradrenaline reuptake inhibitors

✍ Scribed by Roland Bischoff; Deborah J. Hamilton; Nicola K. Jobson; Andrew Sutherland

Publisher: John Wiley and Sons
Year: 2007
Tongue: French
Weight: 117 KB
Volume: 50
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.1242

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✦ Synopsis

Abstract

A new approach for the stereoselective synthesis of guanidine‐derived amino acids, L‐arginine and (+)‐blastidic acid, has been devised which allows the selective incorporation of isotopic labels in both the side chain of the amino acid as well as the guanidine unit. A new asymmetric synthesis of the (S,R)‐diastereomer of reboxetine, an antidepressant, has also been completed which allows the specific incorporation of radiolabelled iodine for SPECT imaging. Copyright © 2007 John Wiley & Sons, Ltd.

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