New approach to estimate nanowear test results through nanoindentation test

A new approach to minimizing the number

A new approach to minimizing the number of animals used in acute toxicity testing and optimizing the information of test results

✍ E. Schütz; H. Fuchs 📂 Article 📅 1982 🏛 Springer-Verlag 🌐 English ⚖ 788 KB

170 acute toxicity determinations, carried out in rats, mice, and guinea pigs after oral and parenteral administration during the past 5 years, using 5 c~/5 9 animals per dose, were evaluated with respect to the possibility of a reduction of animals necessary for obtaining LDs0 values with limits of