New approaches to cancer therapies
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FΓ₯hraeus, Robin; Fischer, Peter; Krausz, Eberhard; Lane, David P.
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Article
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1999
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John Wiley and Sons
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English
β 222 KB
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Inactivation of the tumour suppressors p53 and p16 INK4a or activating mutations in the ras oncogene are the most common genetic alterations found in human cancers. In this review, novel approaches designed to evaluate the effect of targeting intracellular molecules are described and it is shown how