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New Approach to Bicyclo [5.3.0] Ring Systems

✍ Scribed by Deak, Holly L.; Stokes, Suzanne S.; Snapper, Marc L.


Book ID
121235955
Publisher
American Chemical Society
Year
2001
Tongue
English
Weight
50 KB
Volume
123
Category
Article
ISSN
0002-7863

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Facile approach to the bicyclo[5.3.0]dec
✍ Jalluri S Ravi Kumar; Michael F O'Sullivan; Sarah E Reisman; Catherine A Hulford πŸ“‚ Article πŸ“… 2002 πŸ› Elsevier Science 🌐 French βš– 92 KB

An efficient strategy for the rapid construction of the guiane bicyclo[5.3.0]decane ring system from appropriately substituted 4-alkyn-1-ols has been developed. This methodology relies on a MeLi-catalyzed tandem 5-exo-dig cyclization/Claisen rearrangement sequence as the key ring forming step.