New approach for generation of neutralizing antibody against human T-cell leukaemia virus type-I (HTLV-I) using phage clones
โ Scribed by Nurjahan Begum; Sankichi Horiuchi; Yuetsu Tanaka; Norio Yamamoto; Kouji Ichiyama; Naoki Yamamoto
- Book ID
- 117430766
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 257 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0264-410X
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In order to study the antigenicity of envelope 46 kDa glycoprotein (gp46) of human T-cell leukemia virus type-I (HTLV-I), we have generated monoclonal anti-gp46 antibodies (MAbs), REY-7, REY-I I, REY-16, REY-30, MET4 and MET-3 from rats and mice. lmmunoblot and immunofluorexence assays showed that t
A 42-kDa recombinant protein, PX141, consisting of the trans-activator protein encoded by human T-cell leukemia virus (HTLV-I) (tax, antigen) and the amino-terminal fusion peptide of I 2 amino acid residues of the a-peptide encoded by the plasmid pUC I 9 was produced. In order to investigate the imm