Tiazofurin: A new antitumor agent
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Peter J. O'Dwyer; D. Dale Shoemaker; Hiremagalur N. Jayaram; David G. Johns; Dav
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Article
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1984
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Springer US
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English
⚖ 481 KB
Tiazofurin is an interesting drug now entering Phase I trials, with marked preclinical antitumor activity against P388 and L1210 leukemias, and the Lewis lung carcinoma. Schedule dependency favoring frequent administration has been noted. The drug has a novel mechanism of action, being metabolized