New antisickling agent 3,4-dihydro-2,2-dimethyl-2H-1 benzopyran-6-butyric acid
β Scribed by EKONG, DONALD E. U.; OKOGUN, JOSEPH I.; ENYENIHI, VICTORIA U.; BALOGH-NAIR, VALERIA; NAKANISHI, KOJI; NATTA, CLAYTON
- Book ID
- 109697755
- Publisher
- Nature Publishing Group
- Year
- 1975
- Tongue
- English
- Weight
- 532 KB
- Volume
- 258
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/258743a0
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π SIMILAR VOLUMES
The chiral intermediate diol (3S,4R)-trans-3,4-dihydro-3,4-dihydroxy-2,2dimethyl-2H-1-benzopyran-6-carbonitrile 2. was prepared for the total synthesis of a potassium channel opener drug candidate. The stereoselective acetylation of racemic lwas carded out with various lipases among which the lipase
Highly enantioselective reduction of 3,4-dihydro-2,2-dimethyl-2H-l-benzopyran-4-ones 3 s-e by BH3 was achieved in the presence of catalytic amounts of Corey's oxazaborolidine 4 to afford the corresponding 3,4-dihydro-2,2dimetbyl-2H-l-~nzopyran-4-ols 2a-e in quantitative yields. These benzopyran-4-ol
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