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New antimitotic bicyclic peptides, celogentins D–H, and J, from the seeds of Celosia argentea

✍ Scribed by Hayato Suzuki; Hiroshi Morita; Shigeo Iwasaki; Jun'ichi Kobayashi

Book ID
104205426
Publisher
Elsevier Science
Year
2003
Tongue
French
Weight
289 KB
Volume
59
Category
Article
ISSN
0040-4020

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✦ Synopsis

Six new bicyclic peptides, celogentins D -H (1-5) and J ( 6) have been isolated from the seeds of Celosia argentea, and the structures including its absolute stereochemistry were determined by using extensive NMR methods and chemical means. Celogentins E -H (2 -5) and J (6) showed potent inhibition of tubulin polymerization, while the inhibitory activity of celogentin D (1) was modest. Structureactivity relationship study indicates that ring size of the bicyclic ring system including unusual b s -Leu, Trp, and His residues would be important for their biological activity.

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