New anionic polyelectrolyte hydrogel for corneal surgery

✍ Scribed by Honiger, J. ;Couturier, C. ;Goldschmidt, P. ;Maillet, F. ;Kazatchkine, M. D. ;Laroche, L.

• Book ID: 101256067
• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 79 KB
• Volume: 37
• Category: Article
• ISSN: 0021-9304
• DOI: 10.1002/(sici)1097-4636(19971215)37:4<548::aid-jbm14>3.0.co;2-4

✦ Synopsis

A new high-water-content (78%) anionic polyelectrolyte hydrogel was obtained by phase inversion (demixion) of a polymer solution containing 9.0% poly(acrylonitrile sodium methallylsulphonate), 85.0% dimethylformamide, and 6.0% saline solution (0.9% NaCl). The hydrogel is permeable to water, saline, urea, creatinine, glucose, human albumin, and saline-dissolved oxygen. Investigation of the interactions between human serum and surfaces prepared with the new yielded hydrogel, compared to serum interaction with silica-free silicone (RTV), regenerated cellulose (Cuprophan), MMA/PVP copolymer (Lidofilcon), PMMA (Perspex), PTFE (Gore-Tex), and poly(acrylonitrile sodium methallylsulphonate) hemodialysis membrane (AN-69), showed the hydrogel and hemodialysis membrane (both prepared with AN-69 copolymer) to be the only materials devoid of complement (CЈ)-activating ability.