New and traditional serum markers of bone metabolism in the detection of skeletal metastases

✍ Scribed by M. Plebani; D. Bernardi; M. Zaninotto; M. de Paoli; S. Secchiero; L. Sciacovelli

• Publisher: Elsevier Science
• Year: 1996
• Tongue: English
• Weight: 572 KB
• Volume: 29
• Category: Article
• ISSN: 0009-9120
• DOI: 10.1016/0009-9120(95)02001-2

✦ Synopsis

Objectives: The evaluation of "new" and "traditional" markers of osteoblastic and osteoclastic activity, in patients with bone metastases. Design and Methods: Our series consist of 40 patients with clinical, radiological, and scintigraphic evidence of bone metastases, and 40 age-matched healthy subjects. In all samples, traditional markers were evaluated by measuring total alkaline phosphatase (ALP), tartrate-resistant acid phosphatase (TrACP) activity, and osteocalcin (BGP) concentration. To assess new biochemical bone markers, '13one isoenzyme of alkaline phosphatase (ALP-B) activity, carboxyterminal propeptide of type I procollagen (PICP), and carboxyterminal telopeptide of type I collagen (ICTP) concentrations were measured. Results: Our findings showed that the best diagnostic efficiency is provided by ICTP (0.94) followed by total ALP (0.90), ALP-B (0.80), and TrACP (0.76). The efficiency of BGP and PICP was, instead, very low (0.64 and 0.60, respectively). Conclusion: Our results confirm the utility of the new serum markers such as ALP-B and ICTP assays in detecting bone metastases.