𝔖 Bobbio Scriptorium
✦   LIBER   ✦

New and effective route to β-lactams. The reaction of ketene silyl acetals with schiff bases promoted by titanium tetrachloride

✍ Scribed by Iwao Ojima; Shin-ichi Inaba; Katsuhiko Yoshida

Publisher
Elsevier Science
Year
1977
Tongue
French
Weight
207 KB
Volume
18
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

✦ Synopsis

New methods of constructing B-lactam ring are of particular interest in connection with the synthesis of analogues of the naturally occurring anti-biotics such as penicillins, cephalosporins and pachystermines although a variety of synthetic route to B-lactams has been developed.' We wish to describe here a new and-effective route to D-lactams using the reaction of ketene silyl acetals with Schiff bases promoted by titanium tetrachloride.

📜 SIMILAR VOLUMES

Asymmetric synthesis of β-lactams. I. Th
Asymmetric synthesis of β-lactams. I. The reaction of dimethylketene silyl acetal with (S)-alkylidene(1-arylethyl)amines promoted by titanium tetrachloride
✍ Iwao Ojima; Shin-ichi Inaba 📂 Article 📅 1980 🏛 Elsevier Science 🌐 French ⚖ 227 KB

Asymmetric synthesis of 8-lactams by means of the reaction of dimethylketene silyl acetal with (S)-alkylidenetl-arylethyl)amines in the presence of titanium tetrachloride was studied. The extent of the asymmetric induction was in the range of 44-78% (diastereomeric purity 72-898) and the (S)-configu