New Amphiphilic Glycopolymers Based on a Polycaprolactone-maleic anhydride Copolymer Backbone: Characterization by 15N NMR and Application to Colloidal Stabilization of Nanoparticles
✍ Scribed by Otman Otman; Paul Boullanger; Dominique Lafont; Thierry Hamaide
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 404 KB
- Volume
- 209
- Category
- Article
- ISSN
- 1022-1352
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✦ Synopsis
Abstract
8‐Amino‐3,6‐dioxaoctyl α‐D‐mannopyranoside and 8‐amino‐3,6‐dioxaoctyl β‐D‐galactopyranoside were prepared for coupling with a copolymer made from PCL macromonomers and MA. The new glycosyl compounds as well as PCL macromonomers were synthesized by appropriate techniques and fully characterized. The grafting of the latter with the functionalized copolymer was ascertained by ^15^N NMR experiments. The glycopolymers thus obtained were used in conjunction with Pluronic® F‐68 for the stabilization of PCL nanoparticles prepared by the emulsification‐diffusion technique. The stabilization of these nanoparticles upon storage and after centrifugation was investigated as well.
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