New amidino-benzimidazolyl thiophenes: Synthesis and photochemical synthesis

✍ Scribed by Kristina Starčević; David W. Boykin; Grace Karminski-Zamola

• Book ID: 102231736
• Publisher: John Wiley and Sons
• Year: 2003
• Tongue: English
• Weight: 78 KB
• Volume: 14
• Category: Article
• ISSN: 1042-7163
• DOI: 10.1002/hc.10126

✦ Synopsis

Abstract

New amidino‐benzimidazolyl‐substituted bis‐1,2‐(2‐thienyl)ethenes (4, 5, and 6) and benzo[1,2‐ b:4,3‐ b′]dithiophenes (8, 9, and 10) were prepared by the condensation of amidino‐substituted o‐phenylene diamines with corresponding dialdehydes (3 and 7). All prepared amidino‐benzimidazolyl‐substituted compounds are of particular interest, because they can serve as intercalators or groove binders on DNA in anticancer therapy. © 2003 Wiley Periodicals, Inc. Heteroatom Chem 14:218–222, 2003; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.10126