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New Acetylcholinesterase-Inhibitory Pregnane Glycosides of Cynanchum atratum Roots

✍ Scribed by Ki Yong Lee; Sang Hyun Sung; Young Choong Kim

Publisher
John Wiley and Sons
Year
2003
Tongue
German
Weight
160 KB
Volume
86
Category
Article
ISSN
0018-019X

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✦ Synopsis

Abstract

Three new pregnane glycosides, cynatroside A (1), cynatroside B (2), and cynatroside C (3), isolated from the roots of Cynanchum atratum (Asclepiadaceae), were characterized as 7__β__‐{[O‐α‐L‐cymaropyranosyl‐(1→4)‐O‐β‐D‐digitoxopyranosyl‐(1→4)‐β‐D‐oleandropyranosyl]oxy}‐3,4,4a,4b,5,6,7,8,10,10a‐decahydro‐6__α__‐hydroxy‐4b‐ methyl‐2‐(2‐methyl‐3‐furyl)phenanthren‐1(2__H__)‐one (1), 7__β__‐{[O‐β‐D‐cymaropyranosyl‐(1→4)‐O‐α‐L‐diginopyranosyl‐(1→4)‐β‐D‐cymaropyranosyl]oxy}‐3,4,4a,4b,5,6,7,8,10,10a‐decahydro‐2,6__α__‐dihydroxy‐4b‐methyl‐2‐(2‐methyl‐3‐furyl)phenanthren‐1(2__H__)‐one (2), and 7__β__‐{[O‐α‐L‐cymaropyranosyl‐(1→4)‐O‐β‐D‐digitoxopyranosyl‐(1→4)‐β‐L‐cymaropyranosyl]oxy}‐3,4,4a,4b,5,6,7,8,10,10a‐decahydro‐2,6__α__‐dihydroxy‐4b‐methyl‐2‐(2‐methyl‐3‐furyl)phenanthren‐1(2__H__)‐one (3), respectively. In addition, ten known constituents were identified, i.e., cynascyroside D (4), glaucoside C (5), glaucoside D (6), atratoside A (7), 2,4‐dihydroxyacetophenone (8), 4‐hydroxyacetophenone (9), syringic acid (10), azelaic acid (11), suberic acid (12), and succinic acid (13). Among these compounds, 1–4 significantly inhibit acetylcholinesterase activity.

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