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New access to the one-pot solvent-free synthesis of 4,5-dihydro-pyrido[2,3-b][1,4]diazepines and 2,3-dihydro-benzo[b][1,4]diazepines by microwave irradiation

✍ Scribed by Shyamaprosad Goswami; Anita Hazra; Subrata Jana

Publisher: Journal of Heterocyclic Chemistry
Year: 2009
Tongue: English
Weight: 120 KB
Volume: 46
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.148

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✦ Synopsis

Abstract

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A series of diversely substituted pyridodiazepines and benzodiazepines have been synthesized in solvent and catalyst free microwave condition from aryl/heteroaryl diamines and β‐aryl vinyl ketones. The yields of the reactions varied with the substituents attached to the aryl/heteroaryl diamines. This common protocol is equally effective for the synthesis of pyridodiazepines and benzodiazepines with pharmacological interest, though in case of pyridodiazepines required time is comparatively higher than benzodiazepines. J. Heterocyclic Chem., (2009).

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