𝔖 Bobbio Scriptorium
✦   LIBER   ✦

New [99mTc]-cytectrene amine compounds as specific brain imaging agents

✍ Scribed by Dirk Kuntschke; Martin Wenzel; Paul Schulze

Publisher
John Wiley and Sons
Year
1995
Tongue
French
Weight
428 KB
Volume
36
Category
Article
ISSN
0022-2135

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Lipophilic tertiary amines attached to cyclopentadienyl technetium‐99m tricarbonyl (cytectrene) have been prepared with high radiochemical yield and purity. Biodistribution studies in mice showed that [^99m^Tc]‐cytectrenes, containing in their structure an N‐methylpiperidine, were accumulated in the brain up to 2.8 % of injected dose with high brain‐to‐blood ratios at 15 min p.i.^1^. They therefore indicate some potential as brain imaging agents.

It has to be pointed out that the N‐methylpiperidine ester showed similar biological behaviour as the keto derivative. This indicates that the conversion to polar metabolite(s) via hydrolysis of the ester group ‐ as described for [^99m^Tc]‐ECD ‐ is not essential for brain retention.

📜 SIMILAR VOLUMES

Synthesis and radiobiological evaluation
Synthesis and radiobiological evaluation of a new 99mTc-labeled small peptide: 99mTc-YGGSLAK as imaging agent
✍ Kakali De; Susmita Chandra; Santanu Ganguly; Bhart Sarkar; Mridula Misra 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 French ⚖ 375 KB

## Abstract Peptides are known as receptor‐specific molecules that play an important role not only in diagnosis and therapy of neoplastic diseases, but also in the pathogenesis of other diseases. In an effort to develop a peptide‐based radiopharmaceutical for scintigraphic studies, a small peptide

Synthesis and biodistribution of novel 9
Synthesis and biodistribution of novel 99mTc-nitrido methylpiperidine dithioformate derivatives as potential brain imaging agents
✍ Jie Lu; Mingyan Xu; Hongmei Jia; Shuxia Xi; Yimeng Wang; Xuebin Wang 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 French ⚖ 258 KB

## Abstract Three dithioformate ligands with methyl substituted on the piperidine rings, potassium 1‐(2‐methylpiperidine‐1‐yl)‐dithioformate (2‐mp), potassium 1‐(3‐methylpiperidine‐1‐yl)‐dithioformate (3‐mp) and potassium 1‐(4‐methylpiperidine‐1‐yl)‐dithioformate (4‐mp) were synthesized. The corres