✦ LIBER ✦

New (2-Methoxyphenyl)piperazine Derivatives as 5-HT1A Receptor Ligands with Reduced .alpha.1-Adrenergic Activity. Synthesis and Structure-Affinity Relationships

✍ Scribed by Orjales, Aurelio; Alonso-Cires, Luisa; Labeaga, Luis; Corcostegui, Reyes

Book ID: 125494222
Publisher: American Chemical Society
Year: 1995
Tongue: English
Weight: 625 KB
Volume: 38
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm00008a005

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Analogs of the 5-HT1A serotonin antagoni

Analogs of the 5-HT1A serotonin antagonist 1-(2-methoxyphenyl)-4-[4-(2-phthalimido)butyl]piperazine with reduced .alpha.1-adrenergic affinity

✍ Raghupathi, Revathi K.; Rydelek-Fitzgerald, Laura; Teitler, Milt; Glennon, Richa 📂 Article 📅 1991 🏛 American Chemical Society 🌐 English ⚖ 829 KB

A Series of N4-Imidoethyl Derivatives of

A Series of N4-Imidoethyl Derivatives of 1-(2,3-Dihydro-1,4-benzodioxin-5-yl)piperazine as 5-HT1A Receptor Ligands: Synthesis and Structure-Affinity Relationships

✍ van Steen, B. J.; van Wijngaarden, I.; Tulp, M. Th. M.; Soudijn, W. 📂 Article 📅 1995 🏛 American Chemical Society 🌐 English ⚖ 735 KB

ChemInform Abstract: A Series of N4-Imid

ChemInform Abstract: A Series of N4-Imidoethyl Derivatives of 1-(2,3-Dihydro-1,4- benzodioxin-5-yl)piperazine as 5-HT1A Receptor Ligands: Synthesis and Structure-Affinity Relationships.

✍ B. J. VAN STEEN; I. VAN WIJNGAARDEN; M. TH. M. TULP; W. SOUDIJN 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 32 KB

Structure-Activity Relationship Studies

Structure-Activity Relationship Studies of CNS Agents, XXI: Two Derivatives of 1-(o-Methoxyphenyl)piperazine with an Opposite Function at 5-HT1A Receptors

✍ Jerzy L. Mokrosz; Aleksandra Klodzinska; Jan Boksa; Andrzej J. Bojarski; Beata D 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 266 KB 👁 2 views

Synthesis and Structure−Activity Relatio

Synthesis and Structure−Activity Relationships of a New Model of Arylpiperazines. 5. 1 Study of the Physicochemical Influence of the Pharmacophore on 5-HT 1A /α 1 -Adrenergic Receptor Affinity: Synthesis of a New Derivative with Mixed 5-HT 1A /D 2 Antagonist Properties †

✍ López-Rodríguez, María L.; Morcillo, M. José; Fernández, Esther; Porras, Esther; 📂 Article 📅 2001 🏛 American Chemical Society 🌐 English ⚖ 164 KB

1,3-Dioxolane-Based Ligands as Rigid Ana

1,3-Dioxolane-Based Ligands as Rigid Analogues of Naftopidil: Structure–Affinity/Activity Relationships at α1 and 5-HT1A Receptors

✍ Claudia Sorbi; Silvia Franchini; Annalisa Tait; Adolfo Prandi; Rossella Gallesi; 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 246 KB 👁 1 views

## Abstract Conformational restriction of naftopidil led to the discovery of a new class of ligands with a 1,3‐dioxolane (1,3‐oxathiolane, 1,3‐dithiolane) structure that bind to α~1~ adrenoceptor subtypes and 5‐HT~1A~ receptors. Adequate structural modifications address the selectivity toward one o