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New 1,8-peri-annelated tricyclic quinolone antibacterials

✍ Scribed by H. Miao; V. Cecchetti; O. Tabarrini; A. Fravolini

Publisher
Journal of Heterocyclic Chemistry
Year
2000
Tongue
English
Weight
360 KB
Volume
37
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

The synthesis of new tricyclic quinolones, resulting from peri‐annelation of 1,2,4‐oxadiazine moiety at the N‐1/C‐8 position of the pharmacophoric quinolone nucleus, are described. None of the synthesized compounds showed interesting antibacterial activity in vitro against the tested strains, with the exception of Klebsiella pneumoniae which was susceptible to all the compounds at MIC values of 8 μg/ml.

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