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Neutrophil collagenase activation: The role of oxidants and cathepsin G

✍ Scribed by C. Capodici; R. A. Berg

Publisher
SP Birkhäuser Verlag Basel
Year
1991
Tongue
English
Weight
330 KB
Volume
34
Category
Article
ISSN
1420-908X

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## Abstract Gelatinase A (MMP‐2), a matrix metalloproteinase (MMP) involved in tumor invasion and angiogenesis, is secreted as an inactive zymogen (proMMP‐2) and activated by proteolytic cleavage. Here we report that polymorphonuclear neutrophil (PMN)‐derived elastase, cathepsin G, and proteinase‐3