Antineutrophil cytoplasmic antibodies re
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Olaf Wiesner; Kimberly A. Russell; Augustine S. Lee; Dieter E. Jenne; Matteo Tri
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Article
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2004
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John Wiley and Sons
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English
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## Abstract ## Objective Human neutrophil elastase (HNE) and proteinase 3 (PR3) are structurally and functionally related. PR3 is the prominent target antigen for antineutrophil cytoplasmic antibodies (ANCAs) in Wegener's granulomatosis (WG). Reported frequencies of HNE ANCAs in WG and other autoi