Neutron Capture Therapy: Principles and Applications

✍ Scribed by Wolfgang A. G. Sauerwein (auth.), Wolfgang Sauerwein, Andrea Wittig, Raymond Moss, Yoshinobu Nakagawa (eds.)

Publisher: Springer-Verlag Berlin Heidelberg
Year: 2012
Tongue: English
Leaves: 545
Edition: 1
Category: Library

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✦ Synopsis

Neutron capture therapy (NCT) is based on the ability of the non-radioactive isotope boron-10 to capture thermal neutrons with very high probability and immediately to release heavy particles with a path length of one cell diameter, which in principle allows for tumor cell-selective high-LET particle radiotherapy. This book provides a comprehensive summary of the progress made in NCT in recent years. Individual sections cover all important aspects, including neutron sources, boron chemistry, drugs for NCT, dosimetry, and radiation biology. The use of NCT in a variety of malignancies and also some non-malignant diseases is extensively discussed. NCT is clearly shown to be a promising modality at the threshold of wider clinical application. All of the chapters are written by experienced specialists in language that will be readily understood by all participating disciplines.

✦ Table of Contents

Front Matter....Pages i-ix
Principles and Roots of Neutron Capture Therapy....Pages 1-16
Front Matter....Pages 17-17
Fission Reactor-Based Irradiation Facilities for Neutron Capture Therapy....Pages 19-40
Accelerator-Based BNCT....Pages 41-54
Compact Neutron Generator for BNCT....Pages 55-67
Californium-252 as a Neutron Source for BNCT....Pages 69-74
Front Matter....Pages 75-75
Boron Chemistry....Pages 77-98
Boron Compounds: New Candidates for Boron Carriers in BNCT....Pages 99-116
Drugs for BNCT: BSH and BPA....Pages 117-160
Front Matter....Pages 161-161
Boron Analysis and Boron Imaging in BNCT....Pages 163-188
Proteomic Investigations for Boron Neutron Capture Therapy....Pages 189-200
Analysis and Imaging: PET....Pages 201-212
Boron Imaging: Localized Quantitative Detection and Imaging of Boron by Magnetic Resonance....Pages 213-223
Front Matter....Pages 225-225
Physical Dosimetry and Spectral Characterization of Neutron Sources for Neutron Capture Therapy....Pages 227-257
The Clinical Commissioning of Beams for Neutron Capture Therapy....Pages 259-275
Prescribing, Recording and Reporting of BNCT....Pages 277-285
Treatment Planning....Pages 287-326
Front Matter....Pages 327-327
Boron Neutron Capture Therapy: Application of Radiobiological Principles....Pages 329-358
Tolerance of Healthy Tissues and Ideal Radiation Dose on BNCT....Pages 359-365
Front Matter....Pages 367-367
Clinical Trials in BNCT: A Challenging Task....Pages 369-376
External Beam BNCT for Glioblastoma Multiforme....Pages 377-388
Front Matter....Pages 367-367
Clinical Results of Sodium Borocaptate (BSH)-Based Intraoperative Boron Neutron Capture Therapy (IO-BNCT)....Pages 389-397
Boron Neutron Capture Therapy for Malignant Meningiomas....Pages 399-406
Feasibility for Intramedullary Spinal Glioma....Pages 407-415
BNCT for Advanced or Recurrent Head and Neck Cancer....Pages 417-424
Studies on the Possible Application of BNCT to Thyroid Cancer....Pages 425-431
Malignant Melanoma....Pages 433-448
Application of Neutron Capture Therapy for Locally Recurrent Breast Cancer....Pages 449-459
Liver Metastases....Pages 461-503
Boron Neutron Capture Therapy for Children with Malignant Brain Tumors....Pages 505-511
Prevention of Vascular Restenosis After Vascular Angioplasty....Pages 513-520
Boron Neutron Capture Synovectomy....Pages 521-530
Front Matter....Pages 531-531
Managerial Aspects of BNCT at a Nuclear Research Reactor....Pages 533-542
Back Matter....Pages 543-553

✦ Subjects

Radiotherapy; Oncology; Imaging / Radiology

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