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Neutralizing antibodies against Coxsackie B viruses in patients with recent onset of type I diabetes

✍ Scribed by Th. Mertens; D. Grüneklee; H. J. Eggers

Publisher: Springer
Year: 1983
Tongue: English
Weight: 205 KB
Volume: 140
Category: Article
ISSN: 0340-6997
DOI: 10.1007/bf00442666

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✦ Synopsis

In a search for Coxsackie B virus-induced, insulindependent diabetes mellitus (IDDM) we examined sera from 166 selected patients (age 1-17 years) with recent onset of IDDM for specific neutralizing antibodies. All 166 patients investigated had a clinical history of recent infectious illness. Eighty per cent of the patients had antibodies against at least one Coxsackie B virus type. But even among the children studied with antibody titers higher than 256 only in about 44% could a recent Coxsackie B virus infection be serologically demonstrated by determining specific neutralizing IgM antibodies. This result again strengthens the notion that IDDM includes several different etiologic groups, among others possibly Coxsackie B virus infections.

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