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Neutralization of hepatitis B virus (HBV) by human monoclonal antibody against HBV surface antigen (HBsAg) in chimpanzees

✍ Scribed by Se-Ho Kim; Yong Won Shin; Kwang-Won Hong; Ki-Hwan Chang; Kyung-Hwan Ryoo; Sang-Hoon Paik; Jin-Man Kim; Betsy Brotman; Wolfram Pfahler; Alfred M. Prince

Book ID: 113457823
Publisher: Elsevier Science
Year: 2008
Tongue: English
Weight: 199 KB
Volume: 79
Category: Article
ISSN: 0166-3542
DOI: 10.1016/j.antiviral.2008.03.006

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## Abstract Two study chimpanzees were inoculated intravenously with approximately 1,000 chimpanzee infectious doses of hepatitis B virus (HBV), one with subtype adr and one with subtype ayw, each previously incubated with 0.1 ml of a murine monoclonal antibody (IgG ~1(K)~ class) directed against a