Neutralization of CXCL10 accelerates liver regeneration in carbon tetrachloride-induced acute liver injury
β Scribed by Hiroyuki Yoneyama; Yoshiro Kai; Jun Koyama; Kenji Suzuki; Hiroshi Kawachi; Shosaku Narumi; Takafumi Ichida
- Publisher
- Springer
- Year
- 2007
- Tongue
- English
- Weight
- 573 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0918-4287
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Liver regeneration was induced in rats by treatment with CCl,, which results in substantial regenerative activity with a sharp mitotic response 2 days after intoxication. Closely paralleling the mitotic index, we observed fourfold increases in nuclear scaffold nucleoside triphosphatase, an activity
## Abstract This study is focused on the role of UCPβ2 in hepatic oxidative metabolism following acute CCl~4~ administration to rats. UCPβ2 mRNA, almost undetectable in the liver of controls, was significantly increased 24 h after CCl~4~ administration, peaked at 72 h and then tended to disappear.