✍ Scribed by Fari�as, Isabel
No coin nor oath required. For personal study only.
Neurotrophins are important regulators of the development and maintenance of the vertebrate nervous system. Besides their well-established role in promoting neuronal survival during development, in vitro data suggest that they can regulate proliferation, survival, and differentiation of precursor cells. Analysis of the developing peripheral nervous system in mouse strains carrying mutations in genes encoding the neurotrophins and their receptors indicate, however, that lack of neurotrophin signalling results in specific neuronal deficits that are primarily due to neuronal death. Many of these deficits occur before final target encounter.
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Interest in and recognition of equine neurologic disease have advanced in recent years to the point that it is a common part of clinical practice. In this practical and comprehensive clinical reference, clinicians will find the up-to-date resources needed to effectively and confidently recognize, di
Ten points concerning the early development of the human nervous system and that are rarely appreciated in the literature are summarized. Opportune and discriminative comments on prenatal age are included, and a scheme illustrating the 10 points is provided. Teratology 60:39-41, 1999.
Peripheral myelin protein 22 (PMP22) is a component of compact myelin of the peripheral nervous system (PNS). Mutations affecting PMP22 are associated with hereditary neuropathies in humans and rodents. Although mammalian PMP22 is expressed in several tissues, the disease pathology is restricted to