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Neurotoxicity of MDMA (ecstasy): the limitations of scaling from animals to humans

✍ Scribed by Rafael de la Torre; Magí Farré

Book ID
116918451
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
101 KB
Volume
25
Category
Article
ISSN
0165-6147

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The objective of this study was to evaluate the interspecies scaling for therapeutic protein drugs to predict the systemic clearance in humans from animal data. This study was undertaken to examine whether the rule of exponents of Mahmood and Balian for the prediction of clearance of nonprotein drug