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Neurotoxicity by microglia: Mechanisms and potential therapeutic strategy

✍ Scribed by Hideyuki Takeuchi

Book ID
118083286
Publisher
Wiley (Blackwell Publishing)
Year
2010
Tongue
English
Weight
628 KB
Volume
1
Category
Article
ISSN
1759-1961

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Microglia have been shown to be immunostimulated by inflammatory cytokines and produce a number of toxic mediators. Here we report that immunostimulated microglia can synergistically enhance the Nmethyl-D-aspartate (NMDA) receptor-mediated excitotoxicity in rat cerebellar granule cells (CGC) in cult