Neurotoxic Potential of Three Structural Analogs of β-N-oxalyl-α,β-Diaminopropanoic Acid (β-ODAP)
✍ Scribed by Irina A. Omelchenko; Renu K Jain; Mohammed A. Junaid; S.L.N. Rao; Charles N. Allen
- Book ID
- 110400458
- Publisher
- Springer
- Year
- 1999
- Tongue
- English
- Weight
- 650 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0364-3190
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## Abstract An amperometric method for the determination of the neurotoxic amino acid β‐__N__‐oxalyl‐L‐α,β‐diaminopropionic acid (β‐ODAP) using a screen printed carbon electrode (SPCE) is reported. The electrode material was bulk‐modified with manganese dioxide and used as a detector in flow inject
p-N-Oxalyl-L-a$-diaminopropionic acid (P-L-ODAP) is thought to be the causative agent in lathyrism due to its neuroexcitatory and neurotoxic properties. We have recently reported that P-L-ODAF' is also gliotoxic at high concentrations (Bridges et al.: Brain Res 561:262, 1991). Evidence is now presen