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Neurotoxic effects induced by the Drosophila amyloid-β peptide suggest a conserved toxic function

✍ Scribed by Katia Carmine-Simmen; Thomas Proctor; Jakob Tschäpe; Burkhard Poeck; Tilman Triphan; Roland Strauss; Doris Kretzschmar


Book ID
113812283
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
676 KB
Volume
33
Category
Article
ISSN
0969-9961

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## Abstract Studies with in‐vitro‐cultured neurons treated with amyloid‐β (Aβ) peptides demonstrated neuronal loss by apoptosis that is due, at least in part, to the perturbation of intracellular Ca^2+^ homeostasis. In addition, it was shown that an endoplasmic reticulum (ER)‐specific apoptotic pat