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Neurotensin signaling induces intracellular alkalinization and interleukin-8 expression in human pancreatic cancer cells

✍ Scribed by Ulrike Olszewski; Gerhard Hamilton

Book ID
119328867
Publisher
Wiley (John Wiley & Sons)
Year
2009
Tongue
English
Weight
381 KB
Volume
3
Category
Article
ISSN
1574-7891

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Neuropeptides and their corresponding G protein±coupled receptors (GPCRs) are increasingly implicated in the autocrine/paracrine stimulation of growth of human cancers. We report that neurotensin induced rapid Ca 2 mobilization from intracellular stores followed by Ca 2 in¯ux in ®ve human ductal pan