The introduction of levodopa in the late 1960s represented a landmark in the therapy of Parkinson's disease (PD). However, motor complications of chronic levodopa therapy have emerged as a major limitation of this otherwise effective therapy. Advancing medical and surgical treatment of these complic
Neuroprotective Therapy for Parkinson's disease
β Scribed by I.Shoulson and the Parkinson Study Group
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- English
- Weight
- 103 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0885-3185
No coin nor oath required. For personal study only.
β¦ Synopsis
In the context of degenerative disorders of the basal ganglia, neuroprotective therapy refers to interventions that preserve the integrity and function of vulnerable neurons and thereby slow or halt clinical decline. Decoppering therapy for Wilson's disease is the only established neuroprotective therapy, which not only forestalls decline but may reverse deficits and prevent the onset of illness in presymptomatic homozygotes. Based on our expanding knowledge of the pathogenesis of nigral degeneration, neuroprotective therapy may also be an achievable goal for Parkinson's disease.
π SIMILAR VOLUMES
## Abstract The clinical effects of central glutamatergic stimulation by the glycine prodrug milacemide were studied in six patients with Parkinson's disease under doubleβblind, placeboβcontrolled conditions. When administered as monotherapy at a single oral dose of 1,200 mg, the drug increased ove
## Abstract The once fantastic theoretical concept that patients with Parkinson's disease (PD) would receive gene therapy in an attempt to alleviate their symptoms and potentially modify the course of their disease has become a reality. On the basis of positive preclinical data, four different gene