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Neuroprotective effects of memantine in the models of excitotoxicity

✍ Scribed by Ramesh Gupta; Snjezana Zaja-Milatovic; Dejan Milatovic

Book ID
116925684
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
90 KB
Volume
211
Category
Article
ISSN
0378-4274

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## Abstract NMDA receptors are abundant, ubiquitously distributed throughout the brain, fundamental to excitatory neurotransmission, and critical for normal CNS function. However, excessive glutamate overstimulates NMDA receptors, leading to increased intracellular calcium and excitotoxicity. Mitoc