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Neuroprotective effect of methyl lucidone against microglia-mediated neurotoxicity

โœ Scribed by Yanji Cui; Jinji Wu; Sung-Cherl Jung; Gi-Ok Kim; Ryeo Kyeong Ko; Hye-Ja Lee; Eun-Sook Yoo; Hee-Kyoung Kang; Kyoungho Suk; Su-Yong Eun


Book ID
116438652
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
721 KB
Volume
690
Category
Article
ISSN
0014-2999

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โœ Won-Ki Kim; Kwang Ho Ko ๐Ÿ“‚ Article ๐Ÿ“… 1998 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 273 KB

Microglia have been shown to be immunostimulated by inflammatory cytokines and produce a number of toxic mediators. Here we report that immunostimulated microglia can synergistically enhance the Nmethyl-D-aspartate (NMDA) receptor-mediated excitotoxicity in rat cerebellar granule cells (CGC) in cult