Neuroprotective and neurotoxic roles of levodopa (L-DOPA) in neurodegenerative disorders relating to Parkinson's disease
โ Scribed by R. M. Kostrzewa; J. P. Kostrzewa; R. Brus
- Publisher
- Springer
- Year
- 2002
- Tongue
- English
- Weight
- 66 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0939-4451
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Early diagnosis of Parkinson's disease (PD) is important for the potential application of neuroprotective therapies. The purpose of this study was to assess the detection of the early changes of PD by either imaging the dopamine transporter (DAT) or uptake of L-3,4-dihydroxyphenylalanine (L-DOPA). A
## Abstract Glial cell lineโderived neurotrophic factor (GDNF) has been shown to be neuroprotective in animal models of the dopamine deficiency in Parkinson's disease. To examine the role of the extracellular signalโregulated kinases 1 and 2 (ERK1/2) in this process, we infused a single dose of GDN