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Neuroprotective and neurotoxic effects of monoamine oxidase-B inhibitors and derived metabolites under ischemia in PC12 cells

โœ Scribed by Saleh Abu-Raya; Rinat Tabakman; Eran Blaugrund; Victoria Trembovler; Philip Lazarovici


Book ID
114014473
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
222 KB
Volume
434
Category
Article
ISSN
0014-2999

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โœ Saleh Abu-Raya; Eran Blaugrund; Victoria Trembovler; Philip Lazarovici ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 122 KB ๐Ÿ‘ 1 views

Rasagiline (N-propargyl-1R-aminoindan) is a novel, potent, selective, and irreversible inhibitor of monoamine oxidase B (MAO-B), currently in Phase III trials for the treatment of Parkinson disease (PD). Rasagiline was shown to have neuroprotective properties in various in vitro and in vivo models i