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Neuroprotective agent riluzole potentiates postsynaptic GABAA receptor function

✍ Scribed by Y. He; A. Benz; T. Fu; M. Wang; D.F. Covey; C.F. Zorumski; S. Mennerick


Book ID
117187291
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
370 KB
Volume
42
Category
Article
ISSN
0028-3908

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## Abstract We investigated the interaction of riluzole, a therapeutic agent used in amyotrophic lateral sclerosis (ALS), with α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazole propionic acid (AMPA) receptor channels in mouse spinal motor neurons in culture using whole‐cell patch‐clamp recording techniques. K