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Neuroprotective action of group I metabotropic glutamate receptor agonists against oxygen–glucose deprivation-induced neuronal death

✍ Scribed by Anti Kalda; Allen Kaasik; Vitali Vassiljev; Paavo Pokk; Alexander Zharkovsky


Book ID
114005474
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
358 KB
Volume
853
Category
Article
ISSN
0006-8993

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While it is well documented that the overactivation of ionotropic glutamate receptors leads to seizures and excitotoxic injury, little is known about the role of metabotropic glutamate receptors (mGluRs) in epileptogenesis and neuronal injury. Intracerebroventricular (i.c.v.) infusion of the group I