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Neuroprotection by the NMDA receptor-associated open-channel blocker memantine in a photothrombotic model of cerebral focal ischemia in neonatal rat

โœ Scribed by Philip E Stieg; Sumeer Sathi; Steven Warach; Dean A Le; Stuart A Lipton


Book ID
114017170
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
413 KB
Volume
375
Category
Article
ISSN
0014-2999

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## Abstract We have previously reported that prostaglandin A~1~ (PGA~1~) reduces infarct size in rodent models of focal ischemia. This study seeks to elucidate the possible molecular mechanisms underlying PGA~1~'s neuroprotective effects against ischemic injury. Rats were subjected to permanent mid