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Neuroprotection by marine-derived compound, 11-dehydrosinulariolide, in an in vitro Parkinson’s model: a promising candidate for the treatment of Parkinson’s disease

✍ Scribed by Wu-Fu Chen; Chiranjib Chakraborty; Chun-Sung Sung; Chien-Wei Feng; Yen-Hsuan Jean; Yen-You Lin; Han-Chun Hung; Tzu-Yi Huang; Shi-Ying Huang; Thung-Ming Su; Ping-Jyun Sung; Jyh-Horng Sheu; Zhi-Hong Wen

Publisher: Springer-Verlag
Year: 2011
Tongue: English
Weight: 500 KB
Volume: 385
Category: Article
ISSN: 0028-1298
DOI: 10.1007/s00210-011-0710-2

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## Abstract Glial cell line‐derived neurotrophic factor (GDNF) has been shown to be neuroprotective in animal models of the dopamine deficiency in Parkinson's disease. To examine the role of the extracellular signal‐regulated kinases 1 and 2 (ERK1/2) in this process, we infused a single dose of GDN