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Neuroprotectant minocycline depresses glutamatergic neurotransmission and Ca2+ signalling in hippocampal neurons

✍ Scribed by José Carlos González; Javier Egea; María Del Carmen Godino; Francisco J. Fernandez-Gomez; José Sánchez-Prieto; Luís Gandía; Antonio G. García; Joaquín Jordán; Jesús M. Hernández-Guijo

Book ID
109026184
Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
1011 KB
Volume
26
Category
Article
ISSN
0953-816X

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## Abstract Ca^2+^ channels and pyramidal cell Ca^2+^ are involved in hippocampal spreading depression (SD), but their roles remain elusive. Accordingly, we characterized Ca^2+^ changes during SD in CA3 pyramidal neurons and determined whether Ca^2+^ channel antagonists could prevent SD. SD was ind