✦ LIBER ✦

Neuroplasticity in Alzheimer's disease

✍ Scribed by Bruce Teter; J. Wesson Ashford

Publisher: John Wiley and Sons
Year: 2002
Tongue: English
Weight: 277 KB
Volume: 70
Category: Article
ISSN: 0360-4012
DOI: 10.1002/jnr.10441

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Ramon y Cajal proclaimed in 1928 that “once development was ended, the founts of growth and regeneration of the axons and dendrites dried up irrevocably. In the adult centers the nerve paths are something fixed, ended and immutable. Everything must die, nothing may be regenerated. It is for the science of the future to change, if possible, this harsh decree.” (Ramon y Cajal, 1928). In large part, despite the extensive knowledge gained since then, the latter directive has not yet been achieved by ‘modern’ science. Although we know now that Ramon y Cajal's observation on CNS plasticity is largely true (for lower brain and primary cortical structures), there are mechanisms for recovery from CNS injury. These mechanisms, however, may contribute to the vulnerability to neurodegenerative disease. They may also be exploited therapeutically to help alleviate the suffering from neurodegenerative conditions. Published 2002 Wiley‐Liss, Inc.

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