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Neurophysiological mechanisms of the antihypertensive effect of clonidine in the presence of pain

โœ Scribed by Yu. D. Ignatov; E. G. Bogdanov; A. A. Zaitsev; A. O. Khar'kovskii


Publisher
Springer US
Year
1991
Tongue
English
Weight
356 KB
Volume
112
Category
Article
ISSN
0007-4888

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Pharmacokinetic-pharmacodynamic modeling
โœ H. C. Porchet; P. Piletta; P. Dayer ๐Ÿ“‚ Article ๐Ÿ“… 1992 ๐Ÿ› Springer ๐ŸŒ English โš– 685 KB

Although clonidine analgesia appears to be mediated by the same central alpha 2-adrenoceptors that mediate its hypotensive effect, it is short-lasting when compared to the fall in blood pressure. This has been investigated by combined pharmacokinetic-pharmacodynamic analysis in 10 healthy volunteers