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Neuropeptides: keeping the balance between pathogen immunity and immune tolerance

โœ Scribed by Elena Gonzalez-Rey; Doina Ganea; Mario Delgado

Book ID
116383833
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
798 KB
Volume
10
Category
Article
ISSN
1471-4892

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## Abstract Disruption of the programmed deathโ€1 (PDโ€1) pathway leads to breakdown of peripheral tolerance and initiation of autoimmunity. The molecular pathways that mediate this effect remain largely unknown. We report here that PDโ€1 knockout (PDโ€1^โˆ’/โˆ’^) mice develop more severe and sustained Agโ€